Vascular & Endovascular Surgery »  Faculty »  Vascular Surgery »  Marlene Grenon, M.D., C.M.

Marlene Grenon, M.D., C. M.

Assistant Professor
Division of Vascular and Endovascular Surgery

Contact Information

Division of Vascular and Endovascular Surgery, UCSF
400 Parnassus Avenue, A-6110
San Francisco, CA 94143-0957
Phone: (415) 353-2357
Fax: (415) 353-2669

Education

  • 1998, International Space University, Diploma in Space Sciences
  • 1995-00, McGill University, Doctorate of Medicine and Masters of Surgery
  • 2002-04, Harvard Medical School, Master in Medical Sciences - Clinical Investigations

Residencies

  • 2000-02, Dalhousie University, Resident, Cardiac Surgery
  • 2002-06, McGill University, Resident, Cardiac Surgery
  • 2006-07, McGill University, Chief Resident, Cardiac Surgery

Fellowships

  • 2007-09, University of British Columbia, Fellow, Vascular Surgery
  • 2009-10, Arizona Heart Institute, Fellow, Vascular and Endovascular Surgery

Postdoctoral Training

  • 2002-04, Harvard Medical School & Massachussetts Institute of Technology, Research Fellow, Cardiovascular Space Medicine

Biography

Dr. Marlene Grenon was born in Quebec, Canada. She obtained a diploma in space sciences from the International Space University (ISU) in 1998. She graduated from McGill Medical School in 2000 and obtained a Masters' degree from the Scholars in Clinical Science Program of Harvard Medical School along with a post-doctoral fellowship in cardiovascular space medicine and endocrinology from Brigham and Women's Hospital and the Massachusetts Institute of Technology (MIT) in 2004. She then completed training in cardiac surgery at McGill University in 2007, vascular surgery at the University of British Columbia in 2009 and endovascular surgery at the Arizona Heart Institute in 2010. She is a fellow from the Royal College of Physicians and Surgeons of Canada (RCPSC) and maintains a Certificate of Specialist in both cardiac and vascular surgery from RCPSC.

Dr. Grenon is presently an Assistant Professor in the Department of Surgery at UCSF, a Staff surgeon at the VAMC San Francisco and an Adjunct Faculty at the International Space University. She is a member of many professional organizations and has been an invited lecturer at several regional, national and international meetings and conferences. She is the recipient of several awards for research and was one of the finalists in the 2009 Canadian Astronaut selection.

Research Overview

My current research program encompasses two areas:

Lifestyle modifications for peripheral arterial disease (PAD)

It is well known that lifestyle issues including nutrition, physical activity, and stress have a high impact on disease development and readaptation in patients with cardiovascular disease. The evidence for how nutrition, physical activity, and stress affect patients with PAD is less clear. In my research program, we are conducting different clinical studies on how these factors impact PAD.

For example, in one study,"OMEGA-PAD", we are investigating the effects of omega-3 fatty acids (fish oil) in patients with PAD, looking more specifically at endothelial function and inflammation. In another study, the "OMEGA-Bedrest" study we are investigating the effects of physical inactivity on endothelial function, insulin resistance and inflammation, and are also testing a countermeasure (fish oil) for physical inactivity.

These clinical trials parallel research projects in my basic science laboratory studying how fatty acids influence the interactions between monocytes and endothelial cells, two cell lines critical to the development of atherosclerosis. We hope that these studies will help us understand how factors present in everyday life can impact the development of atherosclerotic disease in the lower extremities and how we can target specific therapies or lifestyle modification programs to help with this disease.


Adaptations to the gravitational mechanical unloading environment

What happens during spaceflight is not too different than when people lack physical exercise: the cardiovascular system becomes deconditioned. This part of my research program aims to draw parallels between what we can learn from astronauts flying in space and cardiovascular diseases on earth. Hence, we are conducting studies simulating the effects of microgravity on earth, specifically at the level of the organ ("physiological") and at the level of the cells ("cellular").


 

Clinical Trials

 

Publications

Most recent publications from a total of 43
  1. Nosova EV, Chong KC, Alley HF, Harris WS, Boscardin WJ, Conte MS, Owens CD, Grenon SM. Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease. J Vasc Surg. 2014 Jun 19. View in PubMed
  2. Drudi L, Grenon SM. Women's health in spaceflight. Aviat Space Environ Med. 2014 Jun; 85(6):645-52. View in PubMed
  3. Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. J Vasc Surg. 2014 Aug; 60(2):396-403. View in PubMed
  4. Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM. Short-term physical inactivity impairs vascular function. J Surg Res. 2014 Aug; 190(2):672-82. View in PubMed
  5. Owens CD, Gasper WJ, Walker JP, Alley HF, Conte MS, Grenon SM. Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization. J Vasc Surg. 2014 Apr; 59(4):1016-24. View in PubMed
  6. Grenon SM, Chong K, Alley H, Nosova E, Gasper W, Hiramoto J, Boscardin WJ, Owens CD. Walking disability in patients with peripheral artery disease is associated with arterial endothelial function. J Vasc Surg. 2014 Apr; 59(4):1025-34. View in PubMed
  7. Grenon SM, Conte MS. n-3 polyunsaturated fatty acids to heal the broken heart. Clinical Lipidology. 2013; 8(5):497-500. View in PubMed
  8. Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vasc Med. 2013 Oct; 18(5):263-74. View in PubMed
  9. Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE. Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: insights from the Heart and Soul Study. Vasc Med. 2013 Aug; 18(4):176-84. View in PubMed
  10. Grenon SM, Conte MS, Nosova E, Alley H, Chong K, Harris WS, Vittinghoff E, Owens CD. Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease. J Vasc Surg. 2013 Nov; 58(5):1283-90. View in PubMed
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